Pralatrexate Pharmacology and Clinical Development
نویسندگان
چکیده
منابع مشابه
Pralatrexate pharmacology and clinical development.
Folates are well known to be essential for many cellular processes, including cellular proliferation. As a consequence, antifolates, the fraudulent mimics of folic acid, have been shown to be potent therapeutic agents in many cancers. Over the past several decades, efforts to improve on this class of drugs have met with little success. Recently, one analog specifically designed to have high aff...
متن کاملPralatrexate Pharmacology and Clinical Development Running Title: PRALATREXATE
Folates are well known to be essential for many cellular processes, including cellular proliferation. As a consequence, antifolates, the fraudulent mimics of folic acid, have been shown to be potent therapeutic agents in many cancers. Over the past several decades, efforts to improve on this class of drugs have met with little success. Recently, one analog specifically designed to have high aff...
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INTRODUCTION Clinical pharmacology refers to the study of the safety, pharmacodynamic activity, mechanism of action, pharmacokinetics, metabolism and excretion of a drug in man. METHODS Selected review of topics that provide guidance on practical issues for researchers conducting non-therapeutic investigational research in humans. RESULTS Close attention to the issues highlighted is needed ...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2013
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-12-2251